Couples, who are carriers of or affected by a thalassemia disease either alpha or beta thalassemia Thalassemia
Conditions
Interventions
Spent culture medium collection: collected 2-2.5 mcL of spent culture medium from each embryo drop in both groups.
Group I: SCM contained BF, Group II: SCM only,Spent culture medium collection: colle
Experimental Procedure/Surgery,Experimental Procedure/Surgery
non invasive PGT-M (SCM contained BF),non invasive PGT-M (SCM only)
Sponsors
Chiang Mai University Funding
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Couples, undergoing assisted reproductive technologies treatment at Chiang Mai Fertility Center or Chiang Mai IVF Polyclinic, who are carriers of or affected by a thalassemia disease either alpha or beta thalassemia, and have requested PGT- M for their embryos.
Exclusion criteria
Exclusion criteria: 1. Couples who decline to undergo PGT-M will be excluded. 2. Couples who refuse to adhere to the study protocol will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concordance rate between TE biopsy and niPGT-M at 3 months after end of the intervention concordance rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity at 3 months after end of the intervention Sensitivity ,specificity at 3 months after end of the intervention specificity | — |
Countries
Thailand
Contacts
Public ContactRasrawee Chantrasiri
Chiang Mai University
Outcome results
None listed