Chronic rhinosinusitis with nasal polyps Chronic rhinosinusitis with nasal polyps
Conditions
Interventions
- Endoscopic-guided Triamcinolone acetonide injection to sinus mucosa perioperative and postoperative Endoscopic Sinus Surgery
- Standard postoperative care: normal saline with budesonide nasal irriga
Experimental Drug,Placebo Comparator Drug
Triamcinolone acetonide injection,Control group
Sponsors
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: - Patients with chronic rhinosinusitis with nasal polyps according to EPOS 2020 guideline underwent endoscopic sinus surgery. - Patients with pre-operative paranasal sinus CT demonstrating lesions involving the frontal and ethmoid sinuses. - Patients aged between 18 to 85 years.
Exclusion criteria
Exclusion criteria: - Patients with secondary CRS from cystic fibrosis, granulomatosis with polyangiitis, or sinonasal malignancies. - Patients who have received systemic corticosteroids or biologic therapies with in the last 4 weeks prior to enrollment. - Patients with current acute infections such as acute rhinosinusitis, or upper respiratory tract infection. - Patients with a known history of serious adverse reactions to triamcinolone acetonide or corticosteroids. - Patients with glaucoma. - Patients with history of pituitary tumor. - Pregnant or breastfeeding women. - Patients who are unlikely to comply with study procedures, including follow-up visits or medication adherence, as determined by the research team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lune-Kennedy score 12 week Lune-Kennedy endoscopic score | — |
Secondary
| Measure | Time frame |
|---|---|
| SNOT-22 12 week SNOT-22 questionaire,VAS 12 week VAS score,IOP 6 week contactless IOP measure,serum cortisol level 6 week blood test | — |
Countries
Thailand
Contacts
Public ContactSupitcha Tiawsakul
Ramathibodi Hospital, Mahidol University
Outcome results
None listed