Resensitization rate after initial negative single day antibiotic challenge test in children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20260227003

Enrollment

215

Registered

2026-02-27

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children or adolescent with history of Antibiotic Hypersensitivity with negative initial drug allergy investigation Antibiotic Hypersensitivity Reaction Drug Challenge Tests Resensitization Pediatrics

Interventions

Participants who develop a positive drug challenge test upon retesting,Participants who had a negative drug challenge test upon retesting or tolerate the reexposure to the drugs

Diagnostic,Diagnostic

Positive resensitization,Negative resensitization

Eligibility

Sex/Gender

All

Age

No minimum to 20 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 0-20 years, underwent a one day antibiotic DcT at One-Day Allergy Clinic, Siriraj Hospital, between January 2024 and December 2025, 2. Patients with a negative DCT result after one-day antibiotic DCT

Exclusion criteria

Exclusion criteria: 1. Patients with inconclusive drug challenge test results, 2. Patients who underwent drug challenge testing with alternative drugs, 3. Patients with a history of severe non immediate hypersensitivity reactions including severe cutaneous adverse reactions such as Stevens Johnson syndrome (SJS) toxic epidermal necrolysis (TEN) drug reaction with eosinophilia and systemic symptoms (DRESS) and acute generalized exanthematous pustulosis (AGEP)

Design outcomes

Primary

Measure	Time frame
Antibiotic resensitization rate after a negative one-day drug challenge test in children at least 4 weeks after initial negative one day drug challenge test the proportion of patients who develop a positive drug challenge test upon re exposure compared with those who remain tolerant.	—

Secondary

Measure	Time frame
Resensitization rate in beta lactam and non beta lactam antibiotics clinical characteristics of resensitized patients and parental drug related quality of life change at least 4 weeks Proportion percentage, Number of patients with positive repeat drug challenge divided by total number of re exposed patients expressed as percentage with 95 percent confidence interval	—

Countries

Thailand

Contacts

Public ContactTuksaporn Promthes

Faculty of Medicine Siriraj Hospital Mahidol University

tuksaporn.pt@gmail.com024195960

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026