A randomized study comparing time of first adrenaline administration between prefilled syringe technique and standard preparation in non-shockable out-of-hospital cardiac arrest patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260227001

Enrollment

Registered

2026-02-27

Start date

2025-04-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-shockable out of hospital cardiac arrest patients prefilled syringe adrenaline non shockable out of hospital cardiac arrest patients prefilled syringe adrenaline

Interventions

Adrenaline was prepared in prefilled syringes (PFS). All preparations were handled by a licensed pharmacist and stored in opaque, sterile packaging at a controlled room temperature of 23 to 25 celciu

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

pre-filled syringe adrenaline technique ,standard preparation

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 years or older. 2. Patients who experienced or were diagnosed with out-of-hospital cardiac arrest (OHCA) and received resuscitation from the Vajira Hospital EMS team.

Exclusion criteria

Exclusion criteria: 1. Presence of a shockable cardiac rhythm. 2.Evidence of a Do-Not-Resuscitate (DNR) order or advance directive refusing initial resuscitation. 3. Presence of clinical indications for withholding CPR. 4.Administration of adrenaline prior to the arrival of the Advanced Life Support (ALS) Vajira Hospital EMS team. 5. Failure to secure an advanced airway 6. Achievement of Return of Spontaneous Circulation (ROSC) before adrenaline administration.

Design outcomes

Primary

Measure	Time frame
the time-to-first-dose of adrenaline At the time of administration Digital stopwatch	—

Secondary

Measure	Time frame
Any Return of Spontaneous Circulation (ROSC) at the time of resuscitation pulse ,Survival to Hospital Admission at the time referal to hospital pulse ,The rate of sustained Return of Spontaneous Circulation (ROSC) in patients receiving adrenaline within 5 minutes versus patient receiving it after 5 minutes. at the time referal to hospital pulse,Satisfaction of nurses or paramedics regarding adrenaline preparation techniques at the time of resuscitation Likert scale,The incidence of medication preparation-related injuries among nurses or paramedics at the time of first dose adrenaline preparaion self-report	—

Measure

Time frame

Any Return of Spontaneous Circulation (ROSC) at the time of resuscitation pulse ,Survival to Hospital Admission at the time referal to hospital pulse ,The rate of sustained Return of Spontaneous Circulation (ROSC) in patients receiving adrenaline within 5 minutes versus patient receiving it after 5 minutes. at the time referal to hospital pulse,Satisfaction of nurses or paramedics regarding adrenaline preparation techniques at the time of resuscitation Likert scale,The incidence of medication preparation-related injuries among nurses or paramedics at the time of first dose adrenaline preparaion self-report

—

Countries

Thailand

Contacts

Public ContactVeerapat Thipangkul

Vajira hospital

veerapat.thi@nmu.ac.th022443000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026