Hepatocellular Carcinoma Transarterial Chemoembolization Preoperative Carbohydrate Loading Post-Embolization Syndrome Enhanced Recovery After Surgery Insulin Resistance Blood Glucose Randomized Controlled Trial Quality of Life Nutritional Support Liver Neoplasms Carbohydrate Loading Embolization, Therapeutic Metabolic Response Patient Comfort Treatment Outcome
Conditions
Interventions
Participants in the intervention group will receive a preoperative carbohydrate loading beverage consisting of a carbohydrate solution providing approximately 50 grams of carbohydrates in a volume of
Experimental Other,No Intervention No treatment
Carbohydrate loading arm,Control
Sponsors
Faculty of Medicine, Prince of Songkla University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosis of hepatocellular carcinoma according to accepted clinical or radiological criteria. 2. Scheduled to undergo transarterial chemoembolization as part of standard clinical care. 3. Age >= 18 years old
Exclusion criteria
Exclusion criteria: 1. Patients undergoing trans-arterial chemoembolization outside regular hospital working hours. 2. Diabetes mellitus with hemoglobin A1c greater than 8 percent. 3. Fasting plasma glucose level greater than 300 milligrams per deciliter at initial assessment. 4. Type 1 diabetes mellitus. 5. Symptomatic gastroesophageal reflux disease requiring ongoing treatment. 6. History of allergy or hypersensitivity to any component of the carbohydrate beverage. 7. History of aspiration. 8. Child-Pugh classification class B8 or higher. 9. Patients undergoing repeated trans-arterial chemoembolization who have previously participated in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post embolization syndrome 4 to 6 hours after transarterial chemoembolization, postoperative day 1 morning, and 48 hours after the procedure Clinical diagnostic criteria including body temperature, abdominal pain, nausea or vomiting, liver enzyme levels, and white blood cell count | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose level Pre procedure, 4 to 6 hours after transarterial chemoembolization, and postoperative day 1 morning Venous blood glucose measurement,Insulin resistance Pre procedure and postoperative day 1 morning Fasting insulin and glucose based calculation,Pain severity 4 to 6 hours after transarterial chemoembolization and postoperative day 1 morning Visual analog scale pain score,Quality of life Pre procedure and 48 hours after the procedure Five level EuroQol questionnaire,Nutritional status Pre procedure and postoperative day 1 morning Body mass index and clinical nutritional assessment | — |
Countries
Thailand
Contacts
Public ContactChaitong Churuangsuk
Prince of Songkla University
Outcome results
None listed