Comparison of hormonal response to a mixed-meal tolerance test after Laparoscopic Roux-en-Y gastric bypass versus Laparoscopic sleeve gastrectomy with duodenojejunal bypass in super morbidly obese patients. bariatric surgery, mixed-meal tolerance test, obesity
Conditions
Interventions
Sleeve gastrectomy with duodenojejunal bypass is a surgical technique in which the greater curvature of the stomach is resected and separated from the lesser curvature and antrum, reducing the gastric
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
Sleeve gastrectomy with duodenojejunal bypass,Roux-en-Y gastric bypass
Sponsors
The Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University
Thai Red Cross Soceity Fund (2025),The Thai Endocrine Society Research Grants (2024)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with an indication for bariatric surgery 2. BMI 50-60 kg/m2 3. Patients who are motivated to lose weight but have not achieved successful weight reduction despite optimal medical therapy and exercise under physician supervision
Exclusion criteria
Exclusion criteria: 1. Patients with diabetes mellitus. 2. Patients with severe comorbid conditions that contraindicate surgery, such as advanced heart disease or chronic kidney failure. 3. Patients with a history of previous bariatric surgery. 4. Patients with gastroesophageal reflux disease refractory to medical therapy, large hiatal hernia, or endoscopic findings of reflux esophagitis grade C or D, or Barrett esophagus. 5. Patients with psychiatric disorders that impair eating behavior control. 6. Patients with a history of pancreatitis, pancreatic disease, or inflammatory bowel disease. 7. Patients who have used steroids or GLP-1 receptor agonists within the past 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hormonal response Post-operative 6-24 months Mixed-meal tolerance test | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypoglycemia Post-operative 6-24 months Mixed-meal tolerance test | — |
Countries
Thailand
Contacts
Public ContactPrimploy Greeviroj
King Chulalongkorn Memorial Hospital
Outcome results
None listed