Safety and possible adverse effects of an effervescent powder containing turmeric extract Colorectal cancer, Curcuma longa L., Curcumin, Healthy volunteers, Safety evaluation
Conditions
Interventions
Participants received one single-dose pouch of the effervescent powder (equivalent to 500 mg curcuminoids) after a meal for 90 days (3 months), with 4 scheduled visits at the hospital for safety monit
Experimental Dietary Supplement
Effervescent powders from turmeric extracts
Sponsors
Agricultural Research Development Agency
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. This study will recruit 20 healthy volunteers. 2. Eligible participants are male or female adults aged between 18 and 60 years. 3. Participants must be non-smokers 4. Participants have no underlying medical conditions. 5. Participants have no history of allergy to curcumin or turmeric-containing products 6. Participants must not have used turmeric-containing medications or dietary supplements within 3 months prior to study enrollment.
Exclusion criteria
Exclusion criteria: 1. History of allergy to curcumin or other components of the study product. 2. Pregnant or breastfeeding women. 3. History of liver disease or abnormal liver function. 4. Chronic kidney disease (CKD stage 3 or more severe). 5. History of anticoagulant use. 6. Scheduled to undergo surgery during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood and urine value at 90 days between before and after end of the intervention Laboratory results and test by paired t-tests ,blood and urine value between visits (day 0 vs day 30 vs day 90)) Laboratory results and test by ANOVA test,Adverse drug reaction (ADR) At 90 days Events of ADR by Questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic and baseline characteristics of healthy volunteers At day 0 Questionnaire | — |
Countries
Thailand
Contacts
Public ContactChanatip Pramvichai
Mae Fah Luang University
Outcome results
None listed