Postoperative nausea and vomiting(PONV) in patient undergoing laparoscopic abdominal surgery using intravenous patient-controlled analgesia (IV PCA) intravenous patient-controlled analgesia, Postoperative nausea and vomiting, laparoscopic abdominal surgery
Conditions
Interventions
Morphine 1 mg/mL of IV PCA,Fentanyl 10 mcg/mL of IV PCA
Active Comparator Drug,Active Comparator Drug
Morphine,Fentanyl
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective laparoscopic abdominal surgery, including both intraperitoneal and retroperitoneal approaches, 2.Adult patients aged between 18 and 75 years, 3.American Society of Anesthesiologists (ASA) physical status I, II, or III, 4.Patients at high risk for postoperative nausea and vomiting (PONV), defined by an Apfel score of three or higher.
Exclusion criteria
Exclusion criteria: 1.Refusal to participate in the study, 2.Patients undergoing gynecological surgery, 3.Patients receiving combined regional anesthesia, such as central neuraxial blocks or peripheral nerve blocks, 4.History of drug allergy or contraindications to the medications used in this study, 5.Pregnant patients, 6.Chronic kidney disease stage three or higher, 7.Patients with liver failure. Body Mass Index (BMI) of thirty or higher, 8.Patients with obstructive sleep apnea (OSA), 9.Inability to understand or operate the intravenous patient-controlled analgesia (IV PCA) device, 10.Communication barriers, 11.impaired decision-making capacity, 12.Patients with chronic pain conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative nausea at 12, 24, 48 hour postoperatively Incidence of postoperative nausea (Yes/No) | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of vomiting at 12, 24, 48 hour postoperatively Yes/No,Severity of nausea at 12, 24, 48 hour postoperatively visual analog scale,incidence of pruritus at 12, 24, 48 hour postoperatively Yes/No,incidence of respiratory distress at 12, 24, 48 hour postoperatively Yes/No,level of conscious at 12, 24, 48 hour postoperatively sedation score(0,1,2,3),Total opioid consumption at 12, 24, 48 hour postoperatively volume of drug(ml),Patient satisfaction at 48 hour postoperatively 0,1,2,3,4,5 | — |
Countries
Thailand
Contacts
Public ContactKanokwan Pholsan
Faculty of Medicine, Khon Kaen University
Outcome results
None listed