Prophylactic Intravenous Bolus Norepinephrine 4 mcg versus Placebo to Prevent Spinal Hypotension Hypertensive Disorders of Pregnancy (HDP) during Cesarean Section : A Randomized, Double-Blind Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260217006

Enrollment

200

Registered

2026-02-17

Start date

2026-02-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HDP after spinal anesthesia undergoing cesarean section HDP, norepinephrine, spinal hypotension, cesarean section

Interventions

NSS 1 ml intravenous,Norepinephrine 4 mcg intravenous

Placebo Comparator Other,Experimental Drug

Placebo,NE4

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Age at least 18 years 2.American Society of Anesthesiologists (ASA) physical status classification II or III, Term pregnancy (gestational age [GA] at least 37 weeks)

Exclusion criteria

Exclusion criteria: 1.Cerebrovascular disease, complicated pregnancy (abruptio placenta and placenta previa totalis), or fetal abnormalities 2.ther drugs administration except spinal bupivacaine and morphine administration after SA and before baby delivery.

Design outcomes

Primary

Measure	Time frame
spinal hypotension after spinal anesthesia to baby delivery case record form	—

Secondary

Measure	Time frame
vasopressor consumption after spinal anesthesia to baby delivery case record form,Reactive hypertension after spinal anesthesia to baby delivery case record form	—

Countries

Thailand

Contacts

Public ContactRatikorn Anusorntanawat

Medical education center (Chaophrayayommarat hospital), Faculty of medicine, Kasetsart university

netanesth@hotmail.com035514999

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026