Lower mean arterial pressure in vasodilatory shock

Targeting lower mean arterial pressure during vasopressor weaning in vasodilatory shock: a pragmatic randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260216004

Enrollment

282

Registered

2026-02-16

Start date

2026-01-14

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with vasodilatory shock arterial pressure, shock, norepinephrine

Interventions

When participants are stabilized (MAP at least 65 mmHg or more with a consistent dose of vasopressors for at least 2 hours, and evidence of adequate fluid resuscitation) after resuscitation of vasodil

Experimental Other,Experimental Other

Lower MAP group,MAP 65 group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and older 2. Vasodilatory shock 3. Treatment with vasopressors at least 6 hours

Exclusion criteria

Exclusion criteria: 1. Receiving palliative or end-of-life care 2. Known or suspected elevated intracranial pressure or spinal cord injury 3. Untreated coronary artery disease with ischemic symptoms 4. Uncontrolled hypertension (SBP > 180 mmHg despite therapy) 5. Post-cardiac arrest patients

Design outcomes

Primary

Measure	Time frame
Time to vasopressor discontinuation at day 7 7 days Duration	—

Secondary

Measure	Time frame
28 day mortality 28 days percents	—

Countries

Thailand

Contacts

Public ContactChawika Pisitsak

Ramathibodi Hospital

chawika_p@hotmail.com6622011552

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026