Critically ill patients receiving continuous renal replacement therapy hypophosphatemia, CRRT, phosphate-containing solution
Conditions
Interventions
- Participants in the Proactive Strategy group will receive phosphate-containing solutions until CRRT discontinuation.
- The type of solution depends on the anticoagulation protocol: Non-citrate anti
Experimental Other,Active Comparator Other
Proactive strategy,Reactive strategy
Sponsors
Peerapat Thanapongsatorn
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years. 2.Patients undergoing Continuous Renal Replacement Therapy (CRRT) with at least one of the following indications: 2.1 Persistent metabolic abnormalities (e.g., severe metabolic acidosis, hyperkalemia) refractory to intermittent hemodialysis. 2.2 Cerebral edema or risk of cerebral edema (e.g., acute liver failure, acute stroke, hypoxic-ischemic brain injury post-cardiac arrest). 2.3 Fluid overload refractory to medical therapy or intermittent hemodialysis, particularly fluid accumulation > 10% of baseline body weight. 2.4 Requirement for continuous control of fluid, acid-base, and electrolyte balance. 3. Patients requiring mechanical ventilation. 4. Serum phosphorus levels between 2.5 and 5.5 mg/dL within 48 hours of CRRT initiation.
Exclusion criteria
Exclusion criteria: 1.Moribund state by the treating physicians to have a low probability of survival within 24 hours. 2. Volunteers who have received a kidney transplant. 3. Pregnant volunteers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilator-free days at 28 days at 28 days after end of the intervention Duration of ventilator-free days | — |
Secondary
| Measure | Time frame |
|---|---|
| Hyperphosphatemia Within 28 days after intervention phosphorus more than 5.5 mg/dL,severe hypophosphatemia Within 28 days after intervention serum phosphorus less than 0.8 mg/dL,Total days on ventilator Discharge date days on ventilator,Hospital length of stay Discharge date Hospital length of stay,ICU length of stay Discharge date ICU length of stay,Hospital mortality Discharge date Incidence of hospital mortality,Incidence of tracheostomy Discharge date Incidence of tracheostomy,Trajectory of serum Phosphate levels During CRRT Serum phosphorus | — |
Countries
Thailand
Contacts
Public ContactPeerapat Thanapongsatorn
Thammasat University Hospital
Outcome results
None listed