Prediabetes PLWH HIV Prediabetes Metformin Lifestyle modification
Conditions
Interventions
Participants will receive lifestyle modification counseling and metformin 500 mg daily at baseline. At 3 months, laboratory assessments including fasting blood glucose, HbA1c, BUN, and creatinine will
Active Comparator Drug,Active Comparator Behavioral
Metformina and Lifestyle modification arm ,Lifestyle modification arm
Sponsors
Nan hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 70 years at the time of enrollment. 2. Confirmed HIV infection 3.prediabetes defined by HbA1c 5.7 to 6.4 or fasting blood glucose 100 to 125 mg per dL or 2 hour plasma glucose on OGTT 140 to 199 mg per dL. 4. Receiving antiretroviral therapy with a suppressed HIV viral load. 5.Ability and willingness to comply with the study protocol including lifestyle modification and follow up visits.
Exclusion criteria
Exclusion criteria: 1.HIV-infected individuals who are not receiving antiretroviral therapy (ART). 2.Pregnant or breastfeeding women. HIV-infected individuals receiving ART with unsuppressed viral load (defined as HIV-1 RNA above the target level per national guidelines). History of intolerance, contraindication, or significant adverse effects related to metformin use. Inability or unwillingness to comply with the prescribed lifestyle modification or exercise program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is HbA1c (%) as a continuous variable assessed longitudinally over 24 months Baseline to 24 months continuous | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to event Time from randomization to diabetes onset up to 24 months | — |
Countries
Thailand
Contacts
Public ContactApinya Chueasuwan
NAN hospital
Outcome results
None listed