Mild to moderate stress urinary incontinence SUI, CO2 vaginal laser, PRP, PFMT
Conditions
Interventions
Fractional CO2 laser group will have three laser sessions at 1 month interval of transvaginal fractional micro-ablative CO2 laser system (SmartXide2 V2LR, Monalisa Touch, DEKA, Florence, Italy) using
CO2 laser combined PFMT,PRP combined PFMT,PFMT alone
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Astraco Medical Networks LTD.,DEKA Asia Pacific CO.,Ltd.
Eligibility
Sex/Gender
Female
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age more than or equal 18 years old 2. SUI confirmed using 1-h PWT of at least 1 g 3. Mild to moderate SUI (score between 1 and 12 From ICIQ-UI SF) (Thai version of ICIQ-UI SF test-retest reliability was 0.98) 4. Positive cough test 5. Did not use any SUI treatment procedures including laser, PRP, or magnetic stimulation within prior 6 months 6. Did not use vaginal estrogen within prior 3 months 7. Never undergone anti-incontinence procedures
Exclusion criteria
Exclusion criteria: 1. Positive (score more than or equal 3) by OABSS score or the urgency score more than or equal 2 (from OABSS item 3) (Thai version of OABSS test-retest reliability was 0.88) 2. 1-h PWT > 50 g 3. Pelvic organ prolapses > stage II 4. Body mass index (BMI) > 30 kg/m2 5. Acute urinary tract infections 6. Voiding difficulty 7. Urinary retention 8. Overflow urinary incontinence with neurogenic causes 9. History of pelvic radiation 10. Undiagnosed abnormal vaginal bleeding 11. Active and untreated urogenital cancer 12. Active urogenital and pelvic infection (i.e., genital herpes, vaginitis, pelvic inflammatory disease) 13. Hematologic disorder (i.e., coagulopathy, thrombocytopenia, platelet dysfunction) 14. Concurrent use of anti-platelet or anti-coagulant medications 15. Pregnancy 16. Taking corticosteroid, or immunosuppressants 17. Any condition precluding informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreasing of urine leakage 6 months 1 hour pad weight test | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy of treatment by assessing subjective outcomes 6 months International Consultation on Incontinence Questionnaire - Lower Urinary Tract Symptoms Quality of Life ,Efficacy of treatment by assessing subjective outcomes 6 months International Consultation on Incontinence Questionnaire - Female Lower Urinary Tract Symptoms question 11,Efficacy of treatment by assessing subjective outcomes 6 months Patient Global Impression of Improvement score | — |
Countries
Thailand
Contacts
Public ContactKamonwan Sansom
Ramathibodi Hospital
Outcome results
None listed