Surgical outcome of CO2 Laser-Assisted Sclerectomy Surgery (CLASS) with collagen implant in glaucomatous eyes

Surgical Results of CO2 Laser-Assisted Sclerectomy Surgery (CLASS) with collagen implant in glaucomatous eyes studied at Mettapracharak (Wat Rai khing) hospital

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260211002

Enrollment

Registered

2026-02-11

Start date

2022-12-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

open- angle glaucoma Glaucoma Non-penetrating Glaucoma surgery CO2 Laser-Assisted Sclerectomy Surgery (CLASS) Collagen implant

Interventions

non-penetrating glaucoma drainage surgery using CO2 laser to create a scleral lake (a drainage pool) combined with permanent collagen implants

Experimental Procedure/Surgery

non-penetrating glaucoma drainage surgery using CO2 laser

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients who understand the content of the informed consent document of this study and voluntarily give written consent to participate in this study without requiring a proxy 2. Men and women who are 18 years old or older at the time of consent 3.Patients with glaucoma who have an inadequate IOP control 4. Patients who are able to undergo observation for 2 years

Exclusion criteria

Exclusion criteria: 1.Inability to Complete Follow-up 2.Monocular Status (One Eye) Participants with only one functional eye. This includes cases where the other eye is considered blind according to the following criteria: Best Corrected Visual Acuity (BCVA): Worse than 20/400. Visual Field: Restricted to 10 degrees or less. Note: The remaining functional eye will not be enrolled in the study regardless of its BCVA. 3. Uncontrolled Intraocular Pressure (IOP): Extremely high eye pressure ( > 40 mmHg) that exceeds levels safe for the required conjunctival preparation prior to surgery according to the study protocol. 3. Severe Glaucoma Stage: Advanced or severe glaucoma where clinical assessment indicates a need to maintain a target IOP at a level lower than 10 mmHg.

Design outcomes

Primary

Measure	Time frame
Success rate 2 years 1. IOP controlled with/without medication	—

Secondary

Measure	Time frame
Utility index 2 year Visual Function Questionnaire Utility index	—

Countries

Thailand

Contacts

Public Contactkulawan Rojananuangnit

Mettapracharak hospital

kulawan@me.com034388700

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026