Effect of Concentrated Growth Factor (CGF) on Postoperative Recovery After Maxillary Third Molar Extraction

A randomized clinical study on the effectiveness of concentrated growth factors in preventing complications after maxillary third molar extraction

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260210008

Enrollment

100

Registered

2026-02-10

Start date

2024-10-24

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The condition being studied is postoperative complications following maxillary third molar extraction, which include pain, swelling, and alveolar bone loss. Concentrated Growth Factor (CGF) Maxillary Third Molar Extraction Postoperative Complications Pain Management Alveolar Bone Regeneration Soft Tissue Healing Platelet-Rich Products

Interventions

Application of autologous Concentrated Growth Factor (CGF) into the extraction socket of impacted maxillary third molars following surgical extraction to assess the effectiveness in reducing postopera

Experimental Biological/Vaccine,Active Comparator No treatment

Concentrated Growth Factor (CGF) application,No CGF application (control)

Eligibility

Sex/Gender

All

Age

14 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: 1. Participants aged between 14 to 40 years. 2. Bilaterally and symmetrically impacted maxillary third molars (either horizontally or vertically positioned). 3. Maxillary third molars with difficulty levels of 7-10 on the Pederson classification (based on panoramic radiographs). 4. Ability to provide informed consent and attend all follow-up visits.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1. Patients with systemic diseases that may interfere with healing. 2. Presence of periodontal disease in the treatment area. 3. History of long-term steroid use or radiation therapy, particularly in the head and neck region. 4. Inability or unwillingness to provide informed consent or complete follow-up visits.

Design outcomes

Primary

Measure	Time frame
Pain Level Day 1, Day 3, and Day 7 after the surgery Visual Analog Scale	—

Secondary

Measure	Time frame
Soft Tissue Healing 3 Months Wound Healing Score,Alveolar Bone Regeneration 3 Months Cone Beam Computed Tomography	—

Countries

China

Contacts

Public ContactJunbo Tu

Xian Jiaotong University Stomatology Hospital

tujunbo@xjtu.edu.cn008613891920219

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026