Breast cancer Hereditary cancer risk Anxiety Breast Neoplasms Genetic Counseling Genetic Mutation Anxiety Health Knowledge
Conditions
Interventions
Participants receive a structured genetic counseling program delivered by trained staff. The program includes family history assessment, hereditary breast cancer risk education, discussion of genetic
Structured Genetic Counseling Program,control
Sponsors
Khon Kaen University
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Participants who meet one or more of the following criteria will be eligible for inclusion in the study: 1. Breast cancer patients with indications of risk for genetic mutation, defined by any of the following conditions: 1.1 Diagnosis of breast cancer at age 50 years or younger. 1.2 Diagnosis of breast cancer with one of the following characteristics: a. History of recurrent breast cancer on the same side or a second primary cancer, including bilateral breast cancer, synchronous primary cancers diagnosed within less than 6 months, or metachronous primary cancers diagnosed more than 6 months apart. b. Diagnosis of lobular breast cancer (ILC) with a family history of gastric cancer. c. History of sarcoma. d. History of adrenocortical carcinoma, glioma, or choroid plexus carcinoma. e. History of other types of cancer diagnosed at age 45 years or younger. 1.3 Diagnosis of triple negative breast cancer (TNBC). 1.4 Diagnosis of breast cancer at any age with one of the following family history characteristics: a. At least two first or second degree relatives with breast cancer or prostate cancer. b. At least one first or second degree relative with breast cancer diagnosed at age 50 years or younger or a male breast cancer. c. At least one first or second degree relative with ovarian cancer, pancreatic cancer, or sarcoma. d. At least one first or second degree relative diagnosed with cancer at age 45 years or younger. 2. Participants who are conscious, cognitively intact, and able to understand and communicate in Thai. 3. Participants who are willing to participate in the study and provide written informed consent. 4. Participants or their caregivers who have access to a smartphone and are able to use the LINE application.
Exclusion criteria
Exclusion criteria: Participants meeting any of the following criteria will be excluded from the study: 1. Breast cancer patients who have previously undergone genetic testing for BRCA1, BRCA2, or other hereditary cancer related genes prior to receiving care at the Cancer and General Disease Clinic, Surin Hospital. 2. Breast cancer patients with a history of, or currently receiving treatment for, psychiatric disorders that may impair communication or decision making capacity, such as dementia, schizophrenia, or uncontrolled psychiatric symptoms. 3. Breast cancer patients who are physically debilitated, severely ill, or in a critical medical condition, such as those requiring mechanical ventilation, experiencing shock, in terminal stage disease, or those who are unable to participate continuously in the research activities. 4. Breast cancer patients who are under legal constraints, such as court ordered custody or detention, which may limit their ability to provide independent and voluntary consent to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knowledge of hereditary breast cancer and genetic mutation Baseline and 4 weeks after intervention Researcher-developed genetic knowledge questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| anxiety level Baseline and 4 weeks after intervention State-Trait Anxiety Inventory (STAI) | — |
Countries
Thailand
Contacts
Public ContactThiya Nusairam
Surin Hospital, Ministry of Public Health, Thailand
Outcome results
None listed