Atrophic rhinitis patients Atrophic rhinitis PRP biological gel autologous Platelet Rich Plasma Platelet Rich Plasma
Conditions
Interventions
Participants in Group A will undergo venipuncture to obtain 25 mL of blood from the brachial vein Blood will be allocated for LFT and CBC and for preparation of PRP gel. The prepared PRP gel 2 mL will
PRP gel ,Placebo gel
Sponsors
Faculty of medicine Khon Kaen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 Patients aged 18 years or older 2 Diagnosed with atrophic rhinitis by an rhinologist based on symptoms and nasal endoscopic evidence of mucosal atrophy or crusting 3 able to provide inform consent and attend follow up visits
Exclusion criteria
Exclusion criteria: 1 History of severe allergy to PRP related components 2 History of sinonasal malignancy 3 Uncontrolled chronic diseases or severe liver or renal disease 4 Current use of anticoagulants or antiplatelet medications 5 Systemic immune mediated diseases 6 Long term use of systemic immunosuppressants or corticosteroids 7 Pregnant or breastfeeding or immunocompromised patients 8 Inability to complete symptom questionnaires or inability to read or write Thai 9 Prior PRP therapy or corticosteroid nasal irrigation or sinonasal surgery within the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lund-Kennedy Endoscopic scores 1, 2 ,3 month after intervention Lund-Kennedy Endoscopic scores | — |
Secondary
| Measure | Time frame |
|---|---|
| Thai-NOSE score 1, 2 ,3 month after intervention Thai-NOSE score ,SNOT-22 score 1, 2 ,3 month after intervention SNOT-22 score,Adverse event 1, 2 ,3 month after intervention Adverse event | — |
Countries
Thailand
Contacts
Public ContactSuthijit Jintatanon
Faculty of medicine, Khon Kaen university
Outcome results
None listed