The Impact of Varicocelectomy on improving Sperm DNA Fragmentation and abnormal Semen Parameters in subfertile men with clinical varicocele (prospective randomized controlled study)

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260208015

Enrollment

100

Registered

2026-02-08

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility Varicocele Sperm DNA fragmentation Semen parameters Varicocelectomy Semen analysis Sperm motility Sperm morphology Sperm DNA integrity

Interventions

Participants will undergo varicocelectomy through sub inguinal approach and do sperm DNA fragmentation test pre and 6 months post Varicocelectomy.,Participants will undergo varicocelectomy through sub

Experimental Procedure/Surgery,Experimental Procedure/Surgery

Varicocelectomy,Varicocelectomy

Eligibility

Sex/Gender

Male

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Male patients less than 50 years old Sub-fertile men Clinical varicocele Abnormal semen parameters per WHO 2021 Elevated sperm DNA fragmentation index (DFI > 15%)

Exclusion criteria

Exclusion criteria: Previous scrotal surgery Hormonal abnormalities Immunocompromised patients Severe oligospermia

Design outcomes

Primary

Measure	Time frame
change in semen parameters after varicocelectomy 3 and 6 months after Varicocelectomy semen analysis	—

Secondary

Measure	Time frame
change in sperm DNA fragmentation index after varicocelectomy 3 and 6 months after Varicocelectomy sperm DNA fragmentation index (DFI)	—

Countries

Egypt

Contacts

Public ContactHamada Esmail

Sohag University

hamada.abdlallah@med.sohag.edu.eg0102693632

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026