Polycystic ovary syndrome Polycystic ovary syndrome Natural estrogen Testosterone
Conditions
Interventions
Oral contraceptives pills ,Oral contraceptives pills
Active Comparator Drug,Active Comparator Drug
17beta-estradiol/nomegestrol acetate,estetrol/drospirenone
Sponsors
Mookrawee Darachai
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age : women 18 - 40 years old 2. Diagnosis : Newly diagnosed cases of PCOS based on the Rotterdam criteria (at least 2 out of 3 features) as referenced in the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023 3. BMI 18 - 33 kg/m2 4. Informed Consent : Ability to provide voluntary written informed consent through a formal consent process 5. Language Literacy : Proficient in reading and writing the Thai language
Exclusion criteria
Exclusion criteria: 1. Pre-existing Medical Conditions : History of cardiovascular disease, kidney disease, adrenal gland disorders, liver disease, breast disease, thyroid abnormalities, or autoimmune diseases (Systemic Lupus Erythematosus or Antiphospholipid Syndrome). 2. Psychiatric History : History of severe psychiatric disorders. 3. Thromboembolism : History of Deep Vein Thrombosis or Pulmonary Embolism. 4. Metabolic Disorders : History of Diabetes Mellitus or other metabolic conditions, including the use of medications or dietary supplements that affect glucose and lipid metabolism. 5. Medication History : Use of steroids, hormonal therapy, or hormonal contraceptives within the past 3 months. 6. Surgical History : History of major surgery within the past 6 months. 7. Allergic History : Known history of allergy to the investigational drug(s). 8. Mobility : Patients who are currently immobile or have restricted mobility. 9. Family History of Deep Vein Thrombosis, Pulmonary Embolism, or Thrombophilia. 10. Smokers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Testosterone levels 3 months Blood test for free testosterone from calculated free testosterone and free androgen index | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic profiles, clinical of hyperandrogegism and quality of life 3 months 1. Blood test for 75 grams oral glucose tolerance test, LDL, HDL, total cholesterol, triglyceride 2. Clinical evaluation by modified Ferriman-Gallwey score and IGA severity scale 3. questionnaires | — |
Countries
Thailand
Contacts
Public ContactMookrawee Darachai
Faculty of Medicine, Khon Kaen University
Outcome results
None listed