Premature Ovarian Insufficiency with Unknown Causes Idiopathic Premature Ovarian Insufficiency Pathogenic Variants Whole-Exome Sequencing
Conditions
Interventions
Patients who were diagnosed ith premature ovarian insufficiency with unknown causes
Other
POI with unknown causes
Sponsors
Graduate Affairs, Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
Female
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Thai women under 40 years of age who have experienced amenorrhea or irregular menstrual cycles for at least four months 2. Have a serum follicle-stimulating hormone level greater than 25 international units per liter 3. Have a normal 46,XX karyotype, 4. Have no history of iatrogenic causes such as chemotherapy, radiotherapy, or bilateral oophorectomy
Exclusion criteria
Exclusion criteria: 1. Individuals with known genetic syndromes associated with premature ovarian insufficiency, autoimmune-related premature ovarian insufficiency 2. Age younger than 18 years 3. Inability to read or write Thai
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathogenic/Likely Pathogenic Variants February 2027 Frequency of Pathogenic/Likely (P/LP) Pathogenic Variants Detected by Whole-Exome Sequencing | — |
Secondary
| Measure | Time frame |
|---|---|
| Benign/Likely Benign Variants Immediately Frequency of Pathogenic/Likely (P/LP) Pathogenic Variants Detected by Whole-Exome Sequencing | — |
Countries
Thailand
Contacts
Public ContactBanthisa Somboon
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed