Patients with horizontal alveolar bone defect requiring dental implant treatment Alveolar bone loss
Conditions
Interventions
Preoperative prophylaxis antibiotics with Amoxicillin 2 g per oral will be given to patients (Clindamycin 600 mg per oral, if patients are allergic to Penicillin). Local anesthesia will be administere
LifeNet Health, USA) and xenograft (Geistlich Bio-Oss
Geistlich Pharma AG, Switzerland) will be used. After application of bone grafting materials. The graft area will be covered with crosslink collagen membrane (OSSIX Plus
Datum Dental, Israel). Membrane holding suture will be done. Periosteum releasing will be done for reapproximating wound edge with tension free. The wound will be sutured with resorbable suture materi
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
Allograft and xenograft,Autograft and xenograft
Sponsors
Faculty of Dentistry, Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Presenting with an edentulous ridge corresponding to one or two missing teeth, 2. The bony defects are classified as Class IV according to the classification of Cawood and Howell, 3. ASA classification I or II, 4. Willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Patients in vulnerable groups such as dementia, psychiatric conditions, or mental retardation, 2. Patients who are pregnant or lactating, 3. Patients who are smokers, 4. Patients who are taking anticoagulant or antiplatelet agents, 5. Presentation of any pathologic lesions at jaw bone such as cyst or tumor, 6. History of radiation therapy at head and neck region, 7. History of chemotherapy, 8. History of taking antiresorptive agents (such as bisphosphonate, receptor activator of nuclear factor Kappa-B ligand inhibitors) or antiangiogenic agents, 9. History of taking immunosuppressive agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone width gain at preoperative, immediate postoperative, and 9 months postoperative CT scan | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone volume conversion rate at preoperative, immediate postoperative, and 9 months postoperative CT scan,Bone resorption at preoperative, immediate postoperative, and 9 months postoperative CT scan,Complications at postoperative Clinical follow-up,Oral health-related quality of life at preoperative, immediate postoperative, and 9 months postoperative Oral Health Impact Profile-14 questionnaire | — |
Countries
Thailand
Contacts
Public ContactChinnachote Khemla
Faculty of Dentistry, Srinakharinwirot University
Outcome results
None listed