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A comparison of prophylactic norepinephrine administration between 4, 6 and 8 microgram IV on hypotension, bradycardia and other side effect after spinal anesthesia in pregnancy during cesarean section : A randomized, single-blind study

A comparison of prophylactic norepinephrine administration between 4, 6 and 8 microgram IV on hypotension, bradycardia and other side effect after spinal anesthesia in pregnancy during cesarean section : A randomized, single-blind study

Status
Recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20260201006
Enrollment
100
Registered
2026-02-01
Start date
2025-11-27
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy hypotension, bradycardia after spinal anesthesia in pregnancy, cesarean section hypotension : SBP below 100 mmHg or less than 90% SBP and HR50-60 bradycardia : HR below 45/min or HR 46-50/min and SBP below 100 mmHg or less than 90% SBP

Interventions

Norepinephrine 4 mcg IV after spinal anesthesia,Norepinephrine 6 mcg IV after spinal anesthesia,Norepinephrine 8 mcg IV after spinal anesthesia
Experimental Drug,Experimental Drug,Experimental Drug

Sponsors

None listed

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Age at least 18 years 2. American Society of Anesthesiologists (ASA) physical status classification II or III, 3. Term pregnancy (gestational age [GA] at least 37 weeks)

Exclusion criteria

Exclusion criteria: 1. High BP (chronic HT, gestational HT, and preeclampsia) 2. Cerebrovascular disease, complicated pregnancy (abruptio placenta and placenta previa totalis), or fetal abnormalities 3. Other drugs administration except spinal bupivacaine and morphine administration after SA and before baby delivery.

Design outcomes

Primary

MeasureTime frame
hypotension before baby delivery case record form

Secondary

MeasureTime frame
bradycardia before baby delivery case record form

Countries

Thailand

Contacts

Public ContactRatikorn anusorntanawat

Chaophrayayommarat Hospital

netanesth@hotmail.com0819424915

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026