1.Postoperative Pain (Ketorolac and Dexketoprofen) 2.Knee Osteoarthritis 3.Total Knee Arthroplasty Ketorolac, Dexketoprofen, Local infiltration analgesia, Total knee arthroplasty, post operative pain
Conditions
Interventions
- A 40 ml Local Infiltration Analgesia (LIA) cocktail consisting of 30 mg Ketorolac mixed with 20 ml of 0.5% Bupivacaine, 0.3 ml of Adrenaline (1:1000), and Normal Saline Solution (NSS) to reach a tot
Active Comparator Drug,Experimental Drug
Ketorolac group ,Dexketoprofen group
Sponsors
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients with primary varus osteoarthritis of the knee. 2. Patients undergoing unilateral total knee arthroplasty (TKA). 3.Patients with a range of motion (ROM) of the knee: extension between 0 to 5 degrees and flexion of at least 120 degrees. 4.Patients with no prior history of knee surgery.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of hypersensitivity or allergy to the study drugs. 2.Patients with a history of prior knee surgery. 3.Patients with a history of prior knee joint infection. 4.Patients with renal impairment (serum creatinine > 1.5 mg/dL). 5.Patients with a history of venous thromboembolism (VTE). 6.Patients with a history of gastrointestinal (GI) bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative pain postoperative at 6,12,24,48,72 hours VAS at rest and on motion,Blood loss postoperative at 24 hours Predicted Blood Loss; PBL | — |
Secondary
| Measure | Time frame |
|---|---|
| Range of motion postoperative at 6,12,24,48,72 hours goniometer ,Complication postoperative at day 0, 1, 2, 3 Medical record form clinical, lab investigation eg. creatinine,Morphine consumption postoperative at day 0, 1, 2, 3 medical record | — |
Countries
Thailand
Contacts
Public ContactSirasit Innarkgolol
Orthopedics department, Faculty of medicine, Chulalongkorn University
Outcome results
None listed