To investigate the effect of CoQ10 prophylaxis on wound healing in patients who underwent orthognathic surgery Postoperative facial swelling Soft tissue regeneration Bone regeneration Functional capacity of the jaws
Conditions
Interventions
The placebo tablets will be prescribed to participants for 2 weeks prior to the surgery.,CoQ10 oral supplement 300 mg/day will be prescribed to participants for 2 weeks prior to the surgery.
Placebo Comparator Drug,Experimental Drug
Control,CoQ10
Sponsors
Faculty of Dentistry, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Non-growing patients (20-45 years old) 2.Healthy status (American Society of Anesthesiologist (ASA) Class I ) 3.Undergoing orthognathic surgery using BSSO technique
Exclusion criteria
Exclusion criteria: 1.History of allergy to medications used in this study 2.History of maxillofacial trauma 3.History of oral lesions or bony lesions 4.History of systemic diseases that influence wound healing and bone remodeling 5.Presence of periodontitis (probing pocket depth of more than 5 mm in different quadrants, having a minimum of six permanent teeth in each quadrant) 6.Currently receiving any kind of herbs and supplements 7.Being unable to attend follow-up appointments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative facial swelling immediately post-op, 1 week post-op, 4 week post-op Face scan, 3D Slicer,soft tissue regeneration 4 week post-op Biomarker; FGF2 TNF-alpha, Col1A1,bone regeneration immediately post-op, 6 month post-op Cone Beam Computed Tomography,the functional capacity of the jaw 4 week post-op, 8 week post-op Maximum mouth opening | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactApitchaya Saibua
Faculty of Dentistry, Chiang Mai University
Outcome results
None listed