Chemotherapy-induced peripheral neuropathy Gynecologic cancer Cancer-related neuropathy Adverse effects of chemotherapy Chemotherapy-induced peripheral neuropathy Exercise therapy Gynecologic cancer Hand-foot exercise CIPN prevention
Conditions
Interventions
Participants in the intervention group will perform a structured hand-foot exercise program for 15 minutes daily during chemotherapy. The exercise program includes stretching and strengthening exercis
Experimental Behavioral,No Intervention Other
Hand-foot exercise program,Standard of care
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older. 2. Diagnosed with ovarian, endometrial, cervical, peritoneal, or vaginal cancer. 3. Initiating a paclitaxel containing chemotherapy regimen administered every 3 weeks for at least 3 cycles. 4. No pre existing peripheral neuropathy (CTCAE neuropathy grade 0). 5. ECOG performance status 0 to 1. 6. Able to ambulate independently and perform hand grasping. 7. Willing to participate in the study and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Peripheral neuropathy from other causes including poorly controlled diabetes mellitus (HbA1c greater than or equal to 7 percent) or diabetic neuropathy, carpal tunnel syndrome, or radiculopathy. 2. History of cerebrovascular disease (stroke). 3. Previous exposure to neurotoxic chemotherapy agents including taxanes, platinum compounds, vinca alkaloids, thalidomide, bortezomib, or epothilones. 4. Prior use of medications known to cause neuropathy including amiodarone, statins, or anti mycobacterial agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemotherapy-induced peripheral neuropathy severity Basline and postchemotherapy cycle 3 Common Terminology Criteria for Adverse Events of neuropathy score | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life Basline and postchemotherapy cycle 3 Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity 4 Item Version | — |
Countries
Thailand
Contacts
Public ContactChanya Rakprasit
Department of Obstetrics and Gynecology. Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed