Effects of Whitening Dentifrices on Color Stability After Bleaching

Effect of Whitening Dentifrices on the Short-Term Color Stability of Teeth after In-Office Bleaching: A Randomized Single-Blind Clinical Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260125003

Enrollment

120

Registered

2026-01-25

Start date

2023-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Bleaching, Tooth Color Stability, Tooth Sensitivity Tooth bleaching, Color stability, Whitening toothpaste, Tooth sensitivity

Interventions

Active Comparator: Toothpaste (Colgate Total 12) Device: Bleaching - Participants used a conventional fluoride toothpaste without a specific whitening claim (Colgate Total 12) twice daily for 12 weeks

Active Comparator Device,Experimental Device,Experimental Device,Experimental Device,Experimental Device,Experimental Device

Conventional Fluoride Toothpaste ,Polyphosphate-Based Whitening Toothpaste,Optical Whitening Toothpaste (Blue Covarine),Charcoal-Based Whitening Toothpaste,Oxygen-Releasing Whitening Toothpaste,Multif

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-50 years 2. Good general (ASA 1) and oral health, 3. At least six fully erupted maxillary anterior teeth free of caries, restorations and periodontal disease,. 4. At least one anterior tooth with a shade of A3 or darker.

Exclusion criteria

Exclusion criteria: 1. Systemic or mucosal disease, 2. Pregnancy or breastfeeding, 3. Fixed orthodontic appliances or anterior restorations, 4. Bleaching treatment within the past 24 months, 5. Smoking or alcohol abuse, 6. Allergy to toothpaste components, 7. Extrinsic or intrinsic stains due to tetracycline or fluorosis, bruxism or other parafunctional habits, 8. Gingival recession, dentin hypersensitivity, or any other condition interfering with color measurement.

Design outcomes

Primary

Measure	Time frame
Post-bleaching color stability (Delta Eab) Baseline (pre-bleaching), immediately after bleaching, 1 week, 4 weeks, and 12 weeks post-bleaching. Tooth color changes were measured with a digital spectrophotometer using the CIELAB system and compared over time.	—

Secondary

Measure	Time frame
Tooth sensitivity 24 hours, 48 hours, and 7 days after bleaching. Tooth sensitivity was assessed using a self-reported Numeric Rating Scale from 0 to 10, with participants recording the highest sensitivity experienced after bleaching.	—

Countries

Turkey

Contacts

Public ContactAdem Gok

Firat University

agok@firat.edu.tr05444142458

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026