Hemodynamic instability (maternal hypotension) associated with spinal anesthesia in cesarean delivery. Cesarean Section Spinal Anesthesia Ropivacaine Bupivacaine Local Anesthetics Maternal hypotension
Conditions
Interventions
Spinal anesthesia with 0.75% Isobaric Ropivacaine 20-25 mg add morphine 0.15 mg,Spinal anesthesia with 0.5% Hyperbaric Bupivacaine 10-12 mg add morphine 0.15 mg
Experimental Drug,Active Comparator Drug
Sponsors
None listed
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective cesarean section under spinal anesthesia. 2.Age between 18 and 35 years. 3.American Society of Anesthesiologists (ASA) physical status I or II. 4.Term pregnancy 5.Singleton pregnancy. 6.Voluntarily provides written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of allergy or adverse reaction to local anesthetic agents used for regional anesthesia. 2.Patients with contraindications to spinal anesthesia with local anesthetic and intrathecal morphine. 3.Patients with obstetric risk factors such as preeclampsia or placenta previa. 4.Patients with chronic pain or a history of continuous opioid use. 5.Patients who are unable to communicate primarily in Thai. 6.Patients with a body mass index (BMI) more than 40. 7.Patients who decline to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maternal hypotension 2 hours maternal blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal bradycardia 2 hours maternal heart rate,Need for vasopressor use 2 hours dose of vasopressor,Duration of blockade 24 hours time of blockade regression,Neonatal outcome 1 and 5 minutes after birth APGAR score | — |
Countries
Thailand
Contacts
Public ContactPhanuthep Chintanakul
Department of anesthesiology , faculty of medicine , Chulalongkorn university
Outcome results
None listed