Chronic obstructive pulmonary disease with acute respiratory failure requiring invasive mechanical ventilation. The study focuses on the risk of post extubation respiratory failure in patients with COPD following planned removal of the endotracheal tube in the intensive care unit. Post extubation respiratory failure may lead to reintubation and is associated with increased morbidity, prolonged intensive care unit and hospital length of stay, and increased mortality. The study evaluates respirato
Conditions
Interventions
This group includes adult patients with chronic obstructive pulmonary disease who required invasive mechanical ventilation and received high flow nasal cannula as the primary method of respiratory sup
Treatment,Treatment
HFNC,NIV
Sponsors
Phrapokklao Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age 40 years or older 2.Confirmed diagnosis of chronic obstructive pulmonary disease 3.Admission to the Medical Intensive Care Unit with acute exacerbation with respiratory failure 4. Requirement for invasive mechanical ventilation for at least 24 hours 5. Receipt of either high flow nasal cannula or noninvasive ventilation as the primary respiratory support immediately after extubation
Exclusion criteria
Exclusion criteria: 1.Presence of tracheostomy at the time of extubation 2.Unplanned or accidental extubation 3.Primary indication for mechanical ventilation other than COPD exacerbation 4. Do not intubate or do not resuscitate orders at the time of extubation 5.Use of both high flow nasal cannula and noninvasive ventilation within the first 48 hours after extubation 6. Transfer to another hospital within 48 hours after extubation 7. Incomplete or inaccessible medical records
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post extubation treatment failure Within 48 hours after extubation Requirement for reintubation or escalation of respiratory support due to recurrent respiratory failure documented in the medical record | — |
Secondary
| Measure | Time frame |
|---|---|
| Intensive care unit length of stay During index hospitalization Number of days from ICU admission to ICU discharge,Hospital length of stay During index hospitalization Number of days from hospital admission to hospital discharge,Mortality Within 28 days after extubation All cause death documented in the medical record,Physiological stability Within the first 24 hours after extubation Vital signs including respiratory rate, heart rate, oxygen saturation, and blood pressure recorded in the medical record | — |
Countries
Thailand
Contacts
Public ContactSurapa Klarod
Internal medicine department
Outcome results
None listed