Effects of Proton Pump Inhibitors for Stress Ulcer Prophylaxis in Critically Ill Patients: A Randomized Control Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260116007

Enrollment

130

Registered

2026-01-16

Start date

2023-02-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intensive care patients Intensive care patients

Interventions

Omeprazole 40 mg IV OD,Standard of care

Experimental Drug,No Intervention No treatment

PPI,Control

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients who admit in intensive care unit

Exclusion criteria

Exclusion criteria: 1. Contraindications to enteral feeding 2. Gastrointestinal bleeding 3. Pneumonia 4. Use of antiplatelet or anticoagulant medications 5. Thrombocytopenia (platelet count <100,000 cells/cu.mm)

Design outcomes

Primary

Measure	Time frame
Pneumonia 30 days Pneumonia diagnosis	—

Secondary

Measure	Time frame
GI bleeding 30 days Gastrointestinal bleeding diagnosis	—

Countries

Thailand

Contacts

Public ContactThan Akkharawanasakun

Chiangrai Prachanukroh hospital

than.akkhr@gmail.com66918581518

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026