HIV infection with CD4 count below 200 cells per microliter and risk of Pneumocystis jirovecii pneumonia HIV Infections
Conditions
Interventions
no prophylactic medication and will start rapid ART within 2 weeks ,oral TMP/SMX at a dose of 80 mg trimethoprim and 400 mg sulfamethoxazole once daily and will start rapid ART within 2 weeks
No prophylaxis ,Oral TMP/SMX
Sponsors
Department of Medicine, Phramongkutklao Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1 Confirmed HIV infection 2 CD4 count below 200 cells per microliter or CD4 percentage below 14 3 Start of ART within 14 days 4 No clinical evidence of PJP
Exclusion criteria
Exclusion criteria: 1 Allergy to TMP-SMX or sulfonamides 2 Pregnant or breastfeeding 3 Hemoglobin below 7 g per dL 4 Platelet count below 75 billion per liter -Neutrophil count below 0.75 billion per liter -Serum potassium above 5.0 mEq per L -Acute liver failure or Child Pugh class C score 10 or higher -TB meningitis or cryptococcal meningitis -Use of TMP-SMX, clindamycin, primaquine, or dapsone
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite outcome of adverse drug events and PJP-associated mortality 24 weeks Relative risk | — |
Secondary
| Measure | Time frame |
|---|---|
| PJP incidence 24 weeks Relative risk,Change in CD4 count 24 weeks Mean different ,HIV viral load suppression 24 weeks Relative risk | — |
Countries
Thailand
Contacts
Public ContactOnrujee Thichina
Phramongkutklao Hospital
Outcome results
None listed