To compare estimated blood loss between patients who underwent total abdominal hysterectomy with or without salpingo-oophorectomy in patients who received Vitamin C and placebo Vitamin C
Conditions
Interventions
intravenous vitamin C 1 g preoperatively and 1 g intraoperatively,Normal saline intravenous 100ml preoperatively and 100ml intraoperatively
Experimental Drug,Placebo Comparator No treatment
Vitamin C,Normal saline
Sponsors
Queen Savang Vadhana Memorial Hospital, Thailand
Eligibility
Sex/Gender
Female
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Female patients who underwent total abdominal hysterectomy, with or without bilateral salpingo-oophorectomy. 2. No bleeding tendency. 3. No history of anticoagulant or thrombolytic drug use within 7 days prior to surgery. 4. No contraindications to vitamin C supplementation (e.g., patients with G6PD deficiency, renal disease, or hepatic disease). 5. No history of allergy to vitamin C.
Exclusion criteria
Exclusion criteria: 1. Inability to communicate in the Thai language. 2. Underwent total abdominal hysterectomy due to gynecologic malignancy. 3. Required emergency total abdominal hysterectomy. 4. History of vitamin C supplementation within 2 weeks prior to surgery. 5. History of smoking. 6. Previous abdominal surgery, such as bowel surgery, cesarean section, appendectomy, oophorectomy, myomectomy, or salpingectomy (e.g., due to ectopic pregnancy or tubal ligation).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimated blood loss after operation Suction and weighing gauze | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in hemoglobin (Hb) and hematocrit (Hct) 1 day before and after operation Complete blood count,Length of hospital stay discharged day | — |
Countries
Thailand
Contacts
Public ContactAektanat Tawornkitpanich
Queen Savang Vadhana Memorial Hospital, Thailand
Outcome results
None listed