The diagnostic accuracy of cortisol measurement at 20 and 40 minutes after 1 microgram low dose ACTH stimulation test in the diagnosis of adrenal insufficiency

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260113002

Enrollment

110

Registered

2026-01-13

Start date

2024-11-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adrenal insufficiency Adrenal insufficiency, 1 microgram low dose ACTH stimulation test, serum cortisol, serum delta cortisol

Interventions

All participants underwent a 1 microg ACTH stimulation test in the morning before 1000 hours. The ACTH was administered intravenously by an endocrine nurse, and a heparin lock was maintained for seria

Experimental Procedure/Surgery

rapid cortisol collection

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. adult patients aged over 20 years 2. suspected of having AI and had serum morning cortisol levels between 3 and 14.6 microg/dL.

Exclusion criteria

Exclusion criteria: 1. Recent systemic glucocorticoid use within 24 hours 2. acute illness or stress 3. pregnancy 4. allergy to ACTH

Design outcomes

Primary

Measure	Time frame
adrenal insuffiicency diagnosis at day of enrollment cortisol level	—

Secondary

Measure	Time frame
adrenal insufficiency date of enrollment cortisol level	—

Countries

Thailand

Contacts

Public Contactworapaka manosroi

Chiang Mai University

worapaka.m@gmail.com0898559353

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026