DIAGNOSTIC ACCURACY OF ULTRASOUND GUIDED FINE NEEDLE ASPIRATION CYTOLOGY OF AXILLARY LYMPH NODES IN BREAST CANCER PATIENTS AFTER NEO-ADJUVANT CHEMOTHERAPY

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260110005

Enrollment

Registered

2026-01-10

Start date

2022-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer specifically Stage IIb and Stage IIIa Breast neoplasms Neoadjuvant therapy Biopsy, Fine-Needle Sensitivity and specificity Developing countries

Interventions

Patients received NAC.Post NAC, USG FNAC of axillary nodes was performed, with ALND as the reference standard to evaluate FNAC accuracy and reduce unnecessary surgery.

Experimental Procedure/Surgery

Ultrasound guided fine needle aspiration cytology (USG FNAC) of axillary lymph nodes performed post neoadjuvant chemotherapy (NAC).

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Adults aged 18 to 60 years 2. both female and male (majority female, 93.9%) 3.Context Post-neoadjuvant chemotherapy (NAC) axillary lymph node staging

Exclusion criteria

Exclusion criteria: 1.Recurrent/metastatic disease 2.Inflammatory breast carcinoma 3.Recurrent/metastatic disease 4.Inflammatory breast carcinoma 5.Cardiomyopathy 6.Progressive disease during NAC

Design outcomes

Primary

Measure	Time frame
Sensitivity, Specificity Positive Predictive Value, Negative Predictive Value post-neoadjuvant chemotherapy (post-NAC), immediately prior to surgery metrics collectively measure diagnostic accuracy, clinical utility, and the feasibility of using USG-FNAC as a triage tool in LMIC settings.,Sensitivity, specificity, PPV NPV All assessments were conducted post neoadjuvant chemotherapy (post NAC):USG FNAC performed on axillary lymph nodes ALND performed immediately after FNAC (reference standard) Sensitivity, spicificity, PPV, NOV	—

Measure

Time frame

Sensitivity, Specificity Positive Predictive Value, Negative Predictive Value post-neoadjuvant chemotherapy (post-NAC), immediately prior to surgery metrics collectively measure diagnostic accuracy, clinical utility, and the feasibility of using USG-FNAC as a triage tool in LMIC settings.,Sensitivity, specificity, PPV NPV All assessments were conducted post neoadjuvant chemotherapy (post NAC):USG FNAC performed on axillary lymph nodes ALND performed immediately after FNAC (reference standard) Sensitivity, spicificity, PPV, NOV

—

Secondary

Measure	Time frame
Sensitivity,Specificity,PPV NPV NA Sensitivity,specificity Pov NOV	—

Countries

Pakistan

Contacts

Public ContactQasim Mehmood

King Edward Medical University (KEMU), Lahore, Pakistan the teaching and academic institution affiliated with Mayo Hospital

qasimmehmood1051@kemu.edu.pk923051611462

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026