Exploring the Disparities Between Short and Standard Myotomy in Peroral Endoscopic Myotomy (POEM) as Treatment Modalities for Achalasia: A Comparative Analysis through Randomized Control Trials

Exploring the Disparities Between Short and Standard Myotomy in Peroral Endoscopic Myotomy (POEM) as Treatment Modalities for Achalasia: A Comparative Analysis through Randomized Control Trials.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260107001

Enrollment

Registered

2026-01-07

Start date

2024-08-29

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult patients with Achalasia Type I or II Achalasia Type I Achalasia Type II Peroral endoscopic myotomy POEM

Interventions

POEM with short esophageal myotomy (5-7 cm),POEM with long esophageal myotomy (8-10 cm)

Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery

Short myotomy,Long myotomy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 years or over diagnosed with Achalasia Type I or II 2. Patients who consent to participate in the study 3. Patients who opt for endoscopic surgery

Exclusion criteria

Exclusion criteria: 1. Patients with a history of, or active, esophageal or gastric perforation 2. Patients with a history of prior esophageal or gastric surgery 3. Patients with active esophagitis at the time of surgery 4. Patients with esophageal cancer 5. Patients unable to tolerate anesthesia (Inability to tolerate sedated upper endoscopy due to cardiopulmonary instability, severe pulmonary disease, or other contraindication to endoscopy) 6. Patients with cirrhosis accompanied by portal hypertension (Cirrhosis with portal hypertension, varices, and/or ascites) 7. Patients with underlying diseases causing portal hypertension 8. Pregnant or breastfeeding women 9. Patients with active gastrointestinal bleeding 10. Patients with coagulopathy

Design outcomes

Primary

Measure	Time frame
Clinical outcome 1 month, 3 months, 6 months and 1 year after intervention Eckardt Score	—

Secondary

Measure	Time frame
Operative and post-operative complications During surgery and postoperatively Clinical observation and chart review,Patient characteristics Baseline (before surgery) Demographic and clinical data collection,LES pressure 6 months post-surgery High-resolution esophageal manometry,24-hour esophageal pH monitoring 3 months post-surgery Ambulatory pH probe measurement,Post-operative GERD 1 year post-surgery or if symptomatic Esophagogastroduodenoscopy (EGD),Total procedure time Day of surgery Recorded from anesthesia start to end of surgery,Duration of hospital stay Post-surgery Recorded in days from admission to discharge	—

Measure

Time frame

Operative and post-operative complications During surgery and postoperatively Clinical observation and chart review,Patient characteristics Baseline (before surgery) Demographic and clinical data collection,LES pressure 6 months post-surgery High-resolution esophageal manometry,24-hour esophageal pH monitoring 3 months post-surgery Ambulatory pH probe measurement,Post-operative GERD 1 year post-surgery or if symptomatic Esophagogastroduodenoscopy (EGD),Total procedure time Day of surgery Recorded from anesthesia start to end of surgery,Duration of hospital stay Post-surgery Recorded in days from admission to discharge

—

Countries

Thailand

Contacts

Public ContactChainarong Phalanusitthepha

Division of General Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital

chainarong.pha@mahidol.edu024198021

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026