Exercise-induced fatigue (characterized by transient decline in physical function, muscle strength reduction, and oxidative stress imbalance) in healthy college students Ascorbic Acid
Conditions
Interventions
Ascorbic Acid-loaded Dissolving Microneedle Patch (post-exercise application)
Experimental Drug
Sponsors
Hebei Normal University
Eligibility
Sex/Gender
Male
Age
18 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1.College students aged 18-30; 2.Healthy, no exercise contraindications; 3.No relevant allergies, intact skin at application site; 4.No antioxidants in 1 month, no strenuous exercise in 48h; 5.Cooperate with the study, sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Not college students or aged outside 18-30; 2.Exercise contraindications/diseases; 3.Relevant allergies or damaged application site skin; 4.Antioxidants in 1 month or strenuous exercise in 48h; 5.Refuse cooperation/informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Countermovement Jump (CMJ) one times, one dayy Countermovement Jump (CMJ) Height: Measured by a jump tester/laser rangefinder at rest, immediately post-fatigue, and 24h post-recovery (standardized jump protocol). | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Malondialdehyde (MDA) Concentration one time, one day Serum Malondialdehyde (MDA) Concentration: Detected via thiobarbituric acid (TBA) method in venous blood samples collected at rest, immediately post-fatigue, and 24h post-recovery.,Serum Malondialdehyde (MDA) one time, one day Detected via thiobarbituric acid (TBA) method in venous blood samples collected at rest, immediately post-fatigue, and 24h post-recovery. | — |
Countries
China
Contacts
Public ContactLao Ba
Hebei Normal University
Outcome results
None listed