Very preterm infants born at less than 32 weeks at risk for hemodynamically significant PDA (hsPDA) associated with pulmonary hemorrhage (PH) preterm, patent ductus arteriosus severity score, IOWA score, pulmonary hemorrhage, intraventricular hemorrhage, prediction
Conditions
Interventions
Very preterm infants
GA less than 32 week, with the IOWA PDAsc are greater than or equal to 6 were classified as high-risk and received medical treatment,Very preterm infants
GA less than 32 week, with the IOWA PDAsc are less than 6 were classified as low-risk and manage conservatively
Screening,Screening
hsPDA group (IOWA PDAsc greater than or equal to 6),Non-hsPDA group (IOWA PDAsc less than 6)
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
12 Hours to 36 Hours
Inclusion criteria
Inclusion criteria: All preterm infants who were born at a gestational age less than 32 weeks and were admitted to the Neonatal Intensive Care Unit (NICU) at Ratchaburi Hospital between between 2024 and 2025.
Exclusion criteria
Exclusion criteria: 1. Infants with any congenital anomalies, including life-threatening conditions such as lung hypoplasia or hydrops fetalis. 2. Infants with congenital heart disease (CHD) other than PDA, except for those with a patent foramen ovale or an atrial septal defect; infants diagnosed with persistent pulmonary hypertension. 3. Infants with incomplete echocardiographic data required to calculate the IOWA score. 4. Infants who died before 12 hours of age. 5. Infants whose parents or guardians declined to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulmonary hemorrage 1 year echocardiographic assessment; PDA diameter indexed to weight, LA:Ao ratio, LVO:RVO ratio, pulmonary venous D and MV E velocity, diastolic flow in the descending aorta, IVRT | — |
Secondary
| Measure | Time frame |
|---|---|
| Bronchopulmonary dysplasia 1 year Clinical diagnosis,Necrotizing enterocolitis 1 year Clinical diagnosis, abdominal X-ray,Intraventricular hemorrhage 1 year Clinical diagnosis, brain ultrasound ,Death 1 year Clinical diagnosis | — |
Countries
Thailand
Contacts
Public ContactPunyaporn Prachumpai
Ratchaburi Hospital
Outcome results
None listed