Effectiveness of Vernonia cinerea versus Murraya siamensis Sprays for Smoking Cessation: A Randomized Controlled Trial

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251229024

Enrollment

102

Registered

2025-12-29

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking, Nicotine addictionTobacco smoking remains one of the leading causes of preventable death worldwide. That responsible for approximately 8 million deaths annually [1]. Despite widespread awareness and available interventions. The smoking cessation remains challenging due to nicotine addiction and behavioral conditioning [2]. Smoking cessation

Interventions

Vernonia cinerea Group: Participants received standardized Vernonia cinerea oral spray containing 10 mg/mL of standardized leaf extract. The extract was manufactured following Good Manufacturing Pract

Experimental Other,Experimental Other

VC group,SM group

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-65 years 2. Current cigarette smoker

Exclusion criteria

Exclusion criteria: 1. Currently using or had used nicotine replacement therapy, varenicline, or bupropion within the past 3 months 2. Had known allergies or hypersensitivity to herbal medications

Design outcomes

Primary

Measure	Time frame
Nicotine cessation 3 mount RCT	—

Secondary

Measure	Time frame
Nicotine cessation 3 mount RCT	—

Countries

Thailand

Contacts

Public ContactWuttiphong Phakdeekul

Assoc.Prof.

wuttiphong.p@ku.th0919519441

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026