Healthy human volunteers with recurrent aphthous stomatitis attending the Oral Medicine Clinic, Faculty of Dentistry, Chiang Mai University, Thailand Recurrent Aphthous Stomatitis, Triamcinolone Acetonide, HATAKABB
Conditions
Interventions
Apply topically 3 times daily for 7 days,Apply topically 3 times daily for 7 days
Experimental Drug,Active Comparator Drug
HATAKABB ,Triamcinolone Acetonide
Sponsors
Faculty of Dentistry, Chiang Mai University
HATAKABB (Sim Tien Hor) Co., Ltd.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age over 18 years 2. Clinically diagnosed with RAS, with an ulcer diameter less than 10 mm 3. Willingness to participate and provide informed consent
Exclusion criteria
Exclusion criteria: 1. Known allergy to HATAKABB Anti-cough Mouth Spray 2. Pregnancy or breastfeeding 3. Presence of RAS secondary to systemic diseases associated with oral ulceration (e.g., Behcet disease, Reiter syndrome, inflammatory bowel disease, cyclic neutropenia of unknown etiology, AIDS, pernicious anemia, nutritional deficiencies) 4. Ulcers caused by bacterial, fungal, or viral infections 5. Use of corticosteroids within the past week 6. Use of analgesics or nonsteroidal anti-inflammatory drugs within the past 48 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ulcer size Baseline and Day 7 Calibrated periodontal probe | — |
Secondary
| Measure | Time frame |
|---|---|
| Healing time Complete ulcer resolution Self-reported by participants,Pain intensity Baseline and Day 7 VAS,Salivary TNF-alpha levels Baseline and Day 7 Commercial enzyme-linked immunosorbent assay | — |
Countries
Thailand
Contacts
Public ContactJitjiroj Ittichaicharoen
Faculty of Dentistry, Chiang Mai University
Outcome results
None listed