Effects of myofunctional therapy on sleep apnea severity in patients with obstructive sleep apnea

Effects of myofunctional therapy on upper airway muscle parameters and apnea hypopnea index in patients with obstructive sleep apnea

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251229018

Enrollment

Registered

2025-12-29

Start date

2025-12-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea Obstructive Sleep Apnea Myofunctional Therapy Upper Airway Muscles Apnea Hypopnea Index Sleep Disorders

Interventions

Participants assigned to the intervention group will perform a structured myofunctional therapy program consisting of oropharyngeal and breathing exercises. The program will be conducted 5 days per we

Experimental Other,Active Comparator Other

myofunctional therapy,upper trapezius stretching

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Male or female patients aged 18 to 65 years 2. Diagnosed with moderate to severe obstructive sleep apnea (Apnea Hypopnea Index more than 15 events/hour) 3. Not currently using continuous positive airway pressure (CPAP) therapy or discontinued CPAP for at least 2 weeks 4. Body mass index less than 29.9 5. Able to understand and perform exercise instructions 6. Willing to participate and provide written informed consent

Exclusion criteria

Exclusion criteria: 1. Uncontrolled cardiovascular, metabolic, or pulmonary diseases 2. Other sleep-related disorders 3. History of surgical treatment for obstructive sleep apnea 4. Ankyloglossia or severe tonsillar hypertrophy 5. Cognitive disorders preventing adherence to exercise instructions 6. Participation in less than 80% of prescribed intervention sessions 7. Voluntary withdrawal from the study

Design outcomes

Primary

Measure	Time frame
Apnea Hypopnea Index Baseline and week 12 Overnight polysomnography,Upper airway muscle parameters Baseline and week 12 Ultrasonography	—

Secondary

Measure	Time frame
Sleep architecture parameters Baseline and week 12 Overnight polysomnography,Tongue muscle strength and endurance Baseline, week 4, week 8, and week 12 Tongue pressure measurement device,Cognitive function Baseline and week 12 Standardized cognitive assessments,Quality of life and sleep-related symptoms Baseline and week 12 Validated questionnaires	—

Countries

Thailand

Contacts

Public ContactSupawit Ittinirundorn

Faculty of Sports Science, Chulalongkorn University

supawit.i@chula.ac.th022181012

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026