The increased of hemoglobin level compared between giving iron sucrose vs ferrous fumarate in patients with cancer, ongoing elective surgery preoperative, iron deficiency anemia, cancer, iron supplement, iron sucrose, ferrous fumarate
Conditions
Interventions
Patients receiving iron sucrose will receive 200 mg per times, trice weekly, until the participants received target dose
The dosage of iron sucrose is calculated by 2.4 x body weight (kg) x (target H
Experimental Drug,Active Comparator Drug
iron sucrose,Ferrous fumarate
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria - Age 20-80 years, which diagnosed with cancer, or suspicious of cancer - Hemoglobin level < 10 g/dL - Patients got iron deficiency status, which can be classify into 2 groups; - Absolute IDA: ferritin < 30, and %T-sat < 20% - Functional IDA: ferritin 30-300 and %T-sat < 20% - Patients should receive iron supplementation at least two weeks prior to surgery. - Patients should go on surgical procedure that classify in high bleeding risk, according to 2022 ESC guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery - Research participants or their legally authorized representatives may provide consent to participate in the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria - Using erythropoiesis stimulating agent during admission, or within 3 months before enrolment - Receiving blood components, or blood product within 1 month before enrolment - The surgical procedure is not palliative surgery - eGFR < 30 mL/min/1.73 m2 - AST and/or ALT higher than 3 times above upper normal limits - Patients whose diagnosed with thalassemia disease - Patients were diagnosed with hematologic malignancies - The patient or their legally authorized representative may refuse to provide consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The increased of hemoglobin level 14 days after intervention Hemoglobin level from complete blood count | — |
Secondary
| Measure | Time frame |
|---|---|
| length of stay in hospital from date of admission to date of discharge length of stay during admission for surgical procedure,ferritin level at date of pre-operative 14 days after intervention ferritin level at date before surgery,Change of hemoglobin level after 30 days post-operatively within 45 days after intervention (post-operative 30 days) hemoglobin level,Hemoglobin level pre-operative 14 days after intervention Hemoglobin level at date before surgery,Number of blood transfusion needed during intervention from date of enrollment to 45 days after intervention number of blood transfusion during intervention,Complications after surgery From date of operation to 30 days post-operation rate of readmission, other complication noted in OPD card of patient,rate of ICU admission during admission from date of admission for surgery to discharge date rate of transfer to intensive care during admission for surgery | — |
Countries
Thailand
Contacts
Public ContactWoramek Manosithisak
Division of Hematology, Department of Internal Medicine, Chiang Mai University
Outcome results
None listed