Comparison of postoperative functional outcomes after Total Knee Arthroplasty in patient with vitamin D deficiency: standard Vitamin D supplement regimen versus single high dose vitamin D

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251223003

Enrollment

Registered

2025-12-23

Start date

2025-09-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative functional outcomes in vitamin D deficient patients undergoing TKA, using Knee Society Score TKA, functional outcome, Vitamin D deficiency, vitamin D high single dose

Interventions

400000 iu single dose of ergocalciferol orally 1 day before surgery ,supplementation for 8 weeks with Ergocalciferol, 40,000 IU weekly, starting 1 day before surgery

Experimental Drug,Experimental Drug

High dose vitamin D ,standard dose

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Patient aged 18-80 years with osteoarthritis of the knee who was willing to undergo Total knee arthroplasty and return for normally scheduled follow-up visits 2. Serum 25(OH)D concentration < 30 ng/ml

Exclusion criteria

Exclusion criteria: 1. American Society of Anesthesiologists (ASA) score >= 4 2. CKD with eGFR < 60 ml/min/1.73m2 or creatinine level > 1.3 mg/dL 3. Granulomatous condition e.g. sarcoidosis, active TB 4. Current cancer 5. Metastatic bone disease or metastatic calcification 6. Severe liver disease or jaundice 7. Active or history of renal stones 8. Malabsorption disorder 9. Pregnant 10. Participants undergoing revision surgery or bilateral total knee replacement 11. Inability to take medication orally 12. Defined as albumin-corrected hypercalcemia > 12 mg/dL 13. Primary hyperparathyroidism

Design outcomes

Primary

Measure	Time frame
knee functional outcome 3 wk, 9 wk post-operative Knee society score,knee functional outcome 3 wk, 9 wk post-operative Time up and go test,Pain 3 wk, 9 wk post-operative Visual analog score	—

Secondary

Measure	Time frame
Vitamin D level 3 wk, 9 wk post-operative Serum total vitamin D level	—

Countries

Thailand

Contacts

Public ContactThanavit Chanchiewvichai

Faculty of Medicine Vajira Hospital, Navamindradhiraj University

thanavit.cha@nmu.ac.th0875460754

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026