This study was conducted in healthy volunteers to evaluate the health-promoting effects of a supplement containing gamma oryzanol mixed with curcumin. The investigation focused on physiological and biochemical indicators of systemic health, including blood chemistry, renal and kidney function, vitamin B12 levels, and inflammatory biomarker. Neuropsychological assessments were also performed to explore potential executive function. Gamma oryzanol, Curcumin, Dietary supplement, Healthy volunteer
Conditions
Interventions
Participants in the experimental group received a dietary supplement containing gamma oryzanol mixed with curcumin in capsule form. The dosage was two capsules once daily after a meal. Each capsule co
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Supplement containing gamma oryzanol mixed with curcumin,Placebo capsule identical in appearance, without active ingredients
Sponsors
Naresuan University
Eligibility
Sex/Gender
All
Age
20 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Thai adults aged 20 to 59 years with a body weight of at least 50 kilograms 2. Body mass index (BMI) between 18.51 and 29.99 3. Normal blood pressure (SBP < 140 mmHg, DBP < 90 mmHg) 4. No history of chronic diseases, including cerebrovascular disease, cardiovascular disease, hypertension, kidney disease, liver disease, cancer, or diabetes mellitus 5. Not pregnant or lactating, and confirmed non-pregnant by a negative urine pregnancy test 6. No history of substance use or drug abuse 7. No depressive symptoms based on the two-question depression screening test 8. Normal cognitive function assessed by the Mini-Mental State Examination 9. Normal vision and hearing 10. Able to read and write in Thai
Exclusion criteria
Exclusion criteria: 1. History of central nervous system or psychiatric disorders 2. Communication, visual, or hearing impairments that interfere with testing 3. Cognitive or perceptual disturbances, such as disorientation or poor cooperation 4. Family history of hereditary neurological or psychiatric diseases 5. History of allergy or hypersensitivity to any components of the investigational product, including curcumin, turmeric (powder or fresh), or other curcumin-containing plants such as galangal and fingerroot; gamma oryzanol, rice bran oil, rice germ, or brown rice; and lactose, cow milk, or other dairy-derived products 6. Individuals with contraindications such as renal impairment, biliary or gallbladder disease, gastrointestinal disorders, hypothyroidism, or pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood chemistry, Liver function, Kidney function, Vitamin B12 levels, C-Reactive Protein Blood, liver and kidney functions, Vitamin B12, and C-reactive protein were assessed at baseline and after 8 weeks of intervention. Automated Hematology Analyzer, Automated clinical chemistry analyzer, Immunoassay | — |
Secondary
| Measure | Time frame |
|---|---|
| Executive function scores At baseline, 4 weeks, and 8 weeks after the start of the intervention. Wisconsin card sorting test, Cognitive battery task | — |
Countries
Thailand
Contacts
Public ContactSutisa Thanoi
Naresuan University
Outcome results
None listed