Liver disease undergo laparoscopic major hepatectomy Hepatectomy, lactate, dexmedetomidine
Conditions
Interventions
dexmedetomidine (4 mcg/ml) infusion 0.5 mcg/kg/hr IV, administered after CO2 insufflation until completion of liver parenchymal transection,0.9%NaCl infusion IV rate to be equivalent to administering
Experimental Drug,Placebo Comparator No treatment
Dexmedetomidine group,Control group
Sponsors
King Chulalongkorn Memorial hospital
Ratchadapisek Research Fund
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective laparoscopic major hepatectomy, defined as liver resection involving three or more segments, performed by the hepatobiliary surgery team, 2. Age between 18 and 70 years, 3. American Society of Anesthesiologists Physical Status (ASA) classification I, II or III
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to participate in the study, 2. Patients with contraindications to dexmedetomidine, such as a history of allergy to the drug, 3. Patients with severe comorbidities, such as cardiovascular, respiratory, or endocrine disorders, 4. Patients with severe bradycardia, such as high-grade atrioventricular block, 5. Patients with psychiatric disorders or those who use psychoactive substances, 6. Patients with a history or family history of malignant hyperthermia, 7. Patients with contraindications to Nefopam, such as a history of seizures or drug allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak serum lactate At immediately after liver parenchymal transection or at 2 hours after liver parenchymal transection level (mmol/L) | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial lactate at immediately after liver parenchymal transection level (mmol/L),Arterial lactate at 2 hours after liver parenchymal transection level (mmol/L),Venous lactate at 6 hours after liver parenchymal transection level (mmol/L),Lactate clearance lactate clearance at 6 hours after liver parenchymal transection percentage,Aspartate Transaminase at 6 hours after liver parenchymal transection Level (IU/L),Alanine Aminotransferase at 6 hours after liver parenchymal transection Level (IU/L),Total bilirubin at 6 hours after liver parenchymal transection level (mg/dL),Direct bilirubin at 6 hours after liver parenchymal transection level (mg/dL),Duration of mechanical ventilation From the end of surgery Duration (hours),Post operative length of hospital stay From the end of surgery duration (days) | — |
Countries
Thailand
Contacts
Public ContactKirada Apisutimaitri
Faculty of medicine, Chulalongkorn university
Outcome results
None listed