Paracetamol overdose Paracetamol, APAP, Thailand
Conditions
Interventions
AST or ALT greater than 1000 U/L, or total bilirubin greater than 2 mg/dL, or INR greater than 1.5,AST or ALT less than 1000 U/L, or total bilirubin less than 2 mg/dL, or INR less than 1.5
Diagnostic,Diagnostic
Hepatotoxicity,No hepatotoxicity
Sponsors
Phrapokklao Research Center
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with ICD-10 code T39.1 who received treatment at Phrapokklao Hospital, Chanthaburi, between January 2020 and July 2025, with paracetamol ingestion at hepatotoxic doses (greater than or equal to 7.5 grams or 150 mg/kg body weight) within 24 hours.
Exclusion criteria
Exclusion criteria: 1. Paracetamol dose below 7.5 grams or 150 mg/kg. 2. Unknown dose or unavailable laboratory data. 3. Repeated supratherapeutic ingestion over 24 hours. 4. Pre-existing severe liver disease or liver failure. 5. Body weight exceeding 100 kg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hepatotoxicity During hospitalization AST or ALT greater than 1000 U/L, or total bilirubin greater than 2 mg/dL, or INR greater than 1.5 | — |
Secondary
| Measure | Time frame |
|---|---|
| risk factors associated with the development of hepatotoxicity During hospitalization 1. Patient age 2. Pre-existing liver disease 3. Time from ingestion to N-acetylcysteine (NAC) administration 4. Body weight | — |
Countries
Thailand
Contacts
Public ContactTanunya Sakdadech
Phrapokklao Hospital
Outcome results
None listed