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Comparison of ultrasound guided pulsed radiofrequency versus hyaluronidase hydrodissection for treatment of carpal tunnel syndrome, a prospective, randomized, controlled clinical study

Comparison of ultrasound guided pulsed radiofrequency versus hyaluronidase hydrodissection for treatment of carpal tunnel syndrome, a prospective, randomized, controlled clinical study

Status
Recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20251220008
Enrollment
56
Registered
2025-12-20
Start date
2025-11-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal tunnel syndrome this study is to compare the clinical efficacy and safety of ultrasound-guided pulsed radiofrequency and hyaluronidase hydrodissection in the treatment of carpal tunnel syndrome. This research seeks to evaluate both techniques in terms of pain relief, functional improvement, nerve conduction parameters, and potential complications, in order to identify the more effective minimally invasive approach for managing carpal tunnel syndrome.

Interventions

Top neuropole needle 100 mm with a 10 mm active tip will be advanced with ultrasound guidance using the in plane technique towards the median nerve. Sensory and motor stimulation will be tested when
Pulsed Radiofrequency:,Hyaluronidase Hydrodissection

Sponsors

Sohag university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Adults aged from 20 to 80 years 2. Clinical diagnosis of CTS with symptoms for at least 3 months 3. Electrophysiological evidence of mild to moderate CTS 4. No previous intervention for CTS in the affected hand

Exclusion criteria

Exclusion criteria: 1. Previous wrist surgery or trauma 2. Medical history of polyneuropathy, thoracic outlet syndrome, or brachial plexopathy 3. Coagulopathy or local infection at injection site 4. Pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
Onset time of significant pain relief 1 month VAS measures pain on a 10-cm line from 0 (no pain) to 10 (worst pain). The patient marks the line, and the distance from the start point is recorded as the pain score.

Secondary

MeasureTime frame
Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) 1weeks and 1-, 3-, and 6-months post-injection BCTQ is measured using two scores the Symptom Severity Scale and the Functional Status Scale. Patients rate symptoms and hand function each item is scored from 1 to 5, and mean scores are calculated.,Cross-sectional area (CSA) baseline and then at 1-, 3-, and 6-months post-injection CSA is measured by ultrasound at the carpal tunnel inlet the median nerve area is traced inside the hyperechoic rim, and the value is recorded.,Sensory nerve conduction velocity (SNCV) baseline and 1, 3, and 6months post-injection SNCV is measured by stimulating a sensory nerve and recording the response. Velocity in meters per second equals distance between electrodes divided by response latency.

Countries

Egypt

Contacts

Public ContactAmany Mohamed

Sohag university

amany_mahmoud_post@med.sohag.edu.eg01095062277

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026