acne scar acne scar
Conditions
Interventions
Beta-glucan hydrogel will be instructed to apply on one side of face twice daily until last scab fallen off,Petrolatum will be instructed to apply on one side of face twice daily until last scab falle
Experimental Drug,Experimental Drug
Beta-glucan hydrogel,Petrolatum
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Male or female participants aged 20 to 60 years. 2. Participants receiving treatment for bilateral facial acne scars with fractional carbon dioxide laser using identical energy settings on both sides of the face. 3. Participants who voluntarily agree to participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding participants 2. History of hypersensitivity or allergy to hydrogel, yeast, or yeast derived products. 3. History of collagen disorders. 4. Presence of active dermatitis, wounds, or skin infection on the face. 5. History of facial herpes simplex infection or active facial herpes infection. 6. History of malignancy, ongoing cancer treatment, or skin cancer at the treatment area. 7. History of immunodeficiency, including HIV infection or AIDS. 8. History of abnormal photosensitivity. 9. History of facial treatment with dermal fillers, botulinum toxin, collagen biostimulators, platelet rich plasma, or thread lifting within 6 months prior to study enrollment. 10. History of laser treatment for facial acne scars within 6 months prior to study enrollment. 11. History of hypertrophic scars or keloids in the treatment area. 12. History of isotretinoin use within 6 months prior to study enrollment. 13. History of treatment with vitamin A or its derivatives within 3 months prior to study enrollment. 14. History of psychiatric disorders. 15. Any condition that, in the investigators judgment, may compromise participant safety or study outcomes. 16. Participants who do not consent to facial photography for treatment evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| wound healing time baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Physician Global Assessment (PGA) of Healing ,Trabsepidermal water loss baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Tewameter,Safety baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Adverse events | — |
Secondary
| Measure | Time frame |
|---|---|
| Pigmentation level baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Antera3D,Redness level baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Antera3D,Red area baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser VISIA,Brown area baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser VISIA,Post laser complications e.g. erythema, crust, edema baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Physician Global Assessment (PGA) of Healing ,Participants assessments of burning, stinging, itching, dryness baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Participants assessments,melanin index baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Mexameter,Erythema index baseline, 1, 2, 3, 4, 5, 6 and 7 days post laser, 2, 3, 4, 8, 12 weeks post laser Mexameter | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Department of Dermatology, Faculty of Medicine Siriraj hospital, Mahidol university
Outcome results
None listed