Patients who wish to remove excess abdominal skin. biopsy, photoprotection
Conditions
Interventions
All volunteers will receive skin-marking tattoos to ensure that each injection session is administered at the exact same locations. Tattoos will be placed at the corners of every grid box, and injecti
Experimental Device,Experimental Device
Combination of hyaluronic acid, polynucleotide and mannitol,NSS
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Male or female Thai participants aged 30 - 60 years. 2. Volunteers who wish to remove excess abdominal skin.
Exclusion criteria
Exclusion criteria: 1. Volunteers who are pregnant, breastfeeding, or have a positive urine pregnancy test. 2. Volunteers with a history of platelet disorders, coagulation abnormalities, anemia, liver disease, cancer, or immunodeficiency disorders. 3. Volunteers who smoke or have a history of heavy alcohol consumption (more than 2 standard drinks per day or more than 5 days per week; 1 standard drink = 10 g alcohol, equivalent to 1 can of 5-7% beer, 3 caps of 40-43% whisky/white spirits, or 1 glass of 11-13% wine). 4. Volunteers with dermatitis, wounds, or skin infections in the abdominal area. 5. Volunteers who regularly take hormonal medications or contraceptives (injection or oral forms), or who regularly take NSAIDs. 6. Volunteers who take medications that affect blood coagulation, such as aspirin or anticoagulants. 7. Volunteers with abdominal striae (stretch marks). 8. Volunteers with a history of abdominal skin tightening or laser treatment within 6 months prior to study enrollment. 9. Volunteers with a history of keloid or hypertrophic scarring. 10. Volunteers with psychiatric disorders diagnosed by a psychiatrist.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pigmentation Baseline, second treatment, third treatment, 7 days before biopsy, 24 hours before biopsy, 3 hour before biopsy Mexameter,Erythema Baseline, second treatment, third treatment, 7 days before biopsy, 24 hours before biopsy, 3 hour before biopsy Mexameter | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score Baseline, second treatment, third treatment Visual Analog Score,Safety Baseline, second treatment, third treatment, 7 days before biopsy, 24 hours before biopsy, 3 hour before biopsy Adverse event | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital
Outcome results
None listed