Secondary hyperparathyroidism End-stage renal disease Hypocalcemia after parathyroidectomy Calcitriol Parathyroidectomy Hypocalcemia Renal Dialysis Chronic Kidney Disease Phosphate Binders
Conditions
Interventions
Patients receive calcitriol, 2 micrograms orally once daily for three consecutive days before parathyroidectomy, together with standard calcium carbonate supplementation.,Patients do not receive preop
Calcitriol group,no calcitriol
Sponsors
King Narai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with end stage renal disease aged over 18 years who are receiving maintenance hemodialysis or peritoneal dialysis and have persistently elevated serum intact parathyroid hormone above 800 pg per mL for at least six months, together with at least one of the following despite phosphate binder therapy: 1. Serum calcium at least 10.2 mg per dL 2. Serum phosphorus above 5.5 mg per dL 3. Presence of bone pain
Exclusion criteria
Exclusion criteria: 1.Previous parathyroidectomy 2.Thyroid cancer 3.Severe comorbid conditions that contraindicate surgery 4.History of allergy to calcitriol 5.Baseline serum calcium less than 8.6 mg per dL on the day of randomization 6.Pregnant women, 7.Those who declined to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative hypocalcemia Within 72 hours after surgery Serum total calcium measured by laboratory test, level less than 8.0 mg per dL | — |
Secondary
| Measure | Time frame |
|---|---|
| Total calcium supplementation requirement From postoperative day 0 until discharge Amount of intravenous and oral calcium recorded in grams per day,Duration of intravenous calcium infusion From postoperative day 0 until discharge Number of days with continuous intravenous calcium administration,Length of hospital stay From admission for surgery until discharge Total days of inpatient admission recorded in hospital chart,Treatment cost At discharge Total hospitalization cost in Thai Baht from hospital billing system | — |
Countries
Thailand
Contacts
Public ContactTeerapon Muangpasian
King narai hospital
Outcome results
None listed