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A Comparative Study Between Estradiol Plus Dienogest and Dienogest alone for Endometrial Preparation for Hysteroscopic Polypectomy in Reproductive Women Who Presented With Abnormal Uterine Bleeding Due to Endometrial Polyp size less than 2 cm

A Comparative Study Between Estradiol Plus Dienogest and Dienogest alone for Endometrial Preparation for Hysteroscopic Polypectomy in Reproductive Women Who Presented With Abnormal Uterine Bleeding Due to Endometrial Polyp size less than 2 cm

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20251201013
Enrollment
68
Registered
2025-12-01
Start date
2025-12-03
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial preperation before hyteroscopic polypectomy endometrial preperation, endometrial polyp and hyteroscopic polypectomy

Interventions

In the Dienogest group, patients will take tablets No. 1 to 14, each containing 2 mg of dienogest, with all tablets having identical content.,In the Estradiol plus Dienogest group, patients will take
Experimental Drug,Experimental Drug
Dienogest group,Estradiol plus Dienogest group

Sponsors

Bhulmibol Foundation
Lead Sponsor
Obstetric and Gynecologic Department
Collaborator

Eligibility

Sex/Gender
Female
Age
15 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Female patients of reproductive age who present with abnormal uterine bleeding, and who have had regular menstrual cycles for at least six months prior to the onset of abnormal bleeding. 2. The cause of abnormal uterine bleeding must be identified as an endometrial polyp measuring less than 2 centimeters in size. 3. Participants will undergo hysteroscopic surgery (hysteroscopic polypectomy) for removal of the polyp. The procedure will be performed exclusively by Dr. Paweena Phaliwong, M.D. 4. All participants are required to sign the informed consent form prior to enrollment in the study.

Exclusion criteria

Exclusion criteria: 1. Contraindications to taking either of the two medications: combined oral contraceptive pills and progestogen-only oral medication 2. History of allergy to any component of either medication 3. Inability to complete the full medication regimen as required by the study 4. Inability to communicate in or understand the Thai language

Design outcomes

Primary

MeasureTime frame
Endometrial thickness 14 days Endometrial thickness measurement by ultrasound

Secondary

MeasureTime frame
the effectiveness of the two medications leads to differences in surgical outcomes During surgery The results of the operation

Countries

Thailand

Contacts

Public ContactDr. Paweena Phaliwong

Bhulmibol Aduyaldej Hospital

p_phaliwong@yahoo.com0898400066

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026