Patients who undergo mechanical mitral valve replacement require lifelong anticoagulation to prevent prosthetic valve thrombosis and systemic thromboembolism. Achieving a therapeutic INR early in the postoperative period is clinically crucial, yet inappropriate initiation doses of warfarin often lead to delayed target INR, bleeding complications, or subtherapeutic anticoagulation. This study focuses on anticoagulation management in postoperative mechanical mitral valve patients and the clinical
Conditions
Interventions
Patients aged 20 years or older who underwent mechanical mitral valve replacement (MVR) at Lampang Hospital between 2018 and 2023. Patients in this group received an initial Warfarin dose of 1.5, 2.0,
Health Services Research
Mechanical MVR patients receiving initial Warfarin 1.5, 2.0, 2.5 mg/day
Sponsors
Lampang Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients aged 20 years or older who underwent mechanical mitral valve replacement surgery at Lampang Hospital between 2018 and 2023. Patients who received an initial warfarin dose of 1.5 mg, 2.0 mg, or 2.5 mg per day.
Exclusion criteria
Exclusion criteria: Patients who received an initial warfarin dose other than 1.5 mg, 2.0 mg, or 2.5 mg per day following mechanical mitral valve replacement surgery. Patients who died during hospitalization or those for whom INR follow-up data were unavailable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to target INR Up to 120 days post-surgery (measured at days 3, 14, 30, 90, and 120) The number of days from the initial Warfarin dose until the first INR level falls within the therapeutic range of 2.5 to 3.5 | — |
Secondary
| Measure | Time frame |
|---|---|
| INR Control Status Days 3, 14, 30, 90, and 120 post-surgery. Classification of patients into 3 groups based on INR levels: Subtherapeutic, In-target, and Supratherapeutic. | — |
Countries
Thailand
Contacts
Public ContactChanin Prakongyot
Lampang Hospital
Outcome results
None listed